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Research at the Division of Molecular Metabolism aims to understand the regulation of mitochondrial function and the role of mitochondrial dysfunction in disease and aging. By combining genetic, biochemical, and structural approaches with animal models and patient material, the division seeks to increase our understanding of mitochondrial disease pathophysiology and develop novel treatment strategies. We are currently seeking 1-2 highly motivated postdoctoral researchers to join the research group of Anna Wredenberg.

Wredenberg group

Our research spans basic and translational aspects of mitochondrial function, from mitochondrial gene expression to understanding the molecular consequences of metabolic derangements in patients with mitochondrial disease. Recently, we have developed a profound interest in how mitochondria function within the metabolic system. For this, we use a combination of genetic and biochemical approaches on genetically modified animal models such as the fruit fly (Drosophila melanogaster) and mouse, as well as on materials derived from patients diagnosed with inborn errors of metabolism.
Learn more about us at www.wredenberglab.com.

Division of Molecular Metabolism

The Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, is located at the newly built Biomedicum laboratory at the Solna campus of Karolinska Institutet. Our research combines molecular biological, biochemical, genetic, and structural studies using model organisms and patient samples to understand various aspects of mitochondrial metabolism and its regulation. We offer an outstanding research environment with close interaction between basic and clinical science at the Centre for Inherited Metabolic Diseases (CMMS) at Karolinska University Hospital, Stockholm, Sweden. Additionally, we provide excellent access to advanced molecular and cell biology resources at the department and the national core facilities at the Science for Life Laboratory.

Duties

Mitochondrial dysfunction is a hallmark of numerous rare and common diseases and is heavily implicated in age-associated diseases and the natural aging process. As a postdoctoral researcher, you will lead and work within a small team to investigate molecular mechanisms of mitochondrial gene expression or dissect the interplay between mitochondrial function and cellular metabolism. The Wredenberg group uses biochemistry, molecular biology, and modern omics approaches, including structural studies, to understand the molecular processes underlying mitochondrial dysfunction and aging progression. In vivo models from the fly or mouse, including conditional knockout strains, will be implemented in this project.

Your profile

We invite applications from enthusiastic and motivated individuals with a Ph D in molecular biology or genetics. Experience in mitochondrial research, biochemistry, molecular biology, mouse genetics, or different omics methods is advantageous. Strong documentation skills and proficiency in spoken and written English are essential. Successful candidates should be able and willing to work collaboratively within a team to pursue their research. Personal suitability is of great importance when evaluating applicants.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.
The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.
Location: Karolinska Institutet, Biomedicum, Solna, Sweden

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete resumé (max 2 pages) A complete list of publications
• A personal motivation letter explaining your research interest (max 1 page)
• Contact information of at least two references

Welcome to apply at the latest December 22nd 2024.
The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Anställningsform: postdoktorala studier | Anställningens omfattning: heltid | Antal lediga befattningar: 1 | Sysselsättningsgrad: 100% | Ort: Solna | Län: Stockholms län | Land: Sweden | Referensnummer: STÖD 2-4626/2024 | Kontakt: Anna Wredenberg anna.wredenberg@ki.se, | Publicerat: 2024-11-28 | Sista ansökningsdag: 2024-12-22